This is an early work by the artist from Brescia signed and dated 1510, as can be seen on the stone slab in the lower section: “HIERONYMI RU/ MANI BRIXIANI/ OPUS. M.D.X. MENSE DECEMBRI”. It depicts the moments after the crucifixion and shows Golgotha and the three empty crosses in the background. The body of Christ is about to be wrapped in a linen cloth before being laid in the tomb, while those who were close to him during his Passion grieve over him: to the right is Joseph of Arimathea, Saints John and Nicodemus, Mary Magdalene, and a devout follower.

The atmosphere is solemn and composed, all gesture is restrained, and the limp body of Christ conveys a profound sense of pathos as we glimpse the signs of his martyrdom and gaze upon the lifeless face of the Son of God. The overall effect is of great equilibrium and harmony of form combining features typical of Lombard artists such as Vincenzo Foppa and Andrea Solario with other Venetian influences from the likes of Giorgione and Titian.The work may have been commissioned by Giovanni Bascheni, agent of Angelo Leonini, bishop of Tivoli, who was provost of the church of San Lorenzo in Brescia, where the painting hung.