Signed and dated 1464, this polyptych in all likelihood comes from the Diedo chapel in the church of Sant’Andrea della Certosa, where it was fitted with an old engraved Gothic frame, decorated with a surmounted Crucifixion and half-figures of prophets, as can be seen in an eighteenth-century engraving by Giovanni Maria Sasso. The five extant panels represent the Madonna enthroned and Child, with Saints Andrew and John the Baptist to the left and Saints Dominic and Peter to the right. Vivarini’s style is characterised by a vivid, almost lacquered colour, underlined by chromatic contrasts such as those, for example, between the blue of the Virgin Mary’s mantle and the deep red of the drape over the throne, or the bright yellow of Peter’s mantle and the ultramarine blue of his garment. The plastic expressive form of the artist is expressed via a sharp line that is at once fluid and elegant. He is able to construct volumes by delineating the outline of the figures, as can be seen in the pleats and folds of the mantles, the drawn faces, and the great attention he lavishes on the curls of the characters’ hair and beards.